|
KMID : 0351619740150010105
|
|
Kyungpook Medical Journal
1974 Volume.15 No. 1 p.105 ~ p.115
|
|
|
Distribution of Human Reservoirs of Typhoid Fever and the Resistance of Salmonella typhi
|
|
李學洙/Lee, Hak Soo
金斗熙/李性寬/Kim, Doo Hie/Lee, Sung Kwan
|
|
|
Abstract
|
|
|
Typhoid fever is prevalent as an endemic disease in Korea and the epidemicity is one of the .persisting problems in social and public health fields. It has not been well reported to health offices in recent years in spite of it being one of the legal communicable diseases. We s4pposA that the control is not easily established because of poor sanitary facilities. It seems that many abortive cases, healthy carriers and convalescent carriers are developing.
This paper presents the carrier rates from various human reservoirs by stool culture, and the resistance to several physicochemical elements of Salmonella typhi isolated from carriers and patients. The period of survey was from April, 1973 1:o March, 1973. The subjects were 8,541 healthy persons, 190 out of 1, 085 persons with past history for three years from 1969 to 1971, 230 patients being ilI with fever and 54 patients´ contacts. The first group was population in service business for customers, who were consulted to test from health offices in Taegu city. The other three groups were consulted from Gun(county) health offices in Gyeongbug province, Korea. The resistance was tested on water temperature, breaching powder, disinfectants (phenol and cresol soap), chemicals (hydrochloric acid, acetic acid, sodium hydroxide and potassium hydroxide) and several therapeutic drugs(chloramphenicol, tetracycline, ampicilIin, bactrim, kanamycin, streptomycin and sulfisoxasol).
Seventeen carriers(0.20%) were detected from 8, 451 persons in service business, one from 190 persons with past history, and one from 54 patients´ contacts. Simultaneously, 19 positve cases were determined from 230 patients. The most of detected carriers and positive patients were between twenty to forty years in age. The carrier rate is not significant among both se :es and serving places. The peak detection of carriers and patients was observed in July.
The corrected carrier rate was 1.3 per 1, 000 of the standard occupational population Kho were cited from the data of population census in 1971. It decre<~sed as compared with 3.7 per 1, 000 in 1963.
S. typhi from carriers ~Tere slightly more sensitive to .~ame antibiotics(chloramphenicol, ampicillin and bactrim) than those from patients, while the resistance of S. typhi from carriers was a little stronger to some chemicals(hydrochloric acid, acetic acid, sodium hydroxide, potassium hydroxide -and breaching powder) than those from patients.
Among 19 strains detected from carriers, 11 survived fo:r eight days at 20 C of water temperature, five for five days at 30 C, all for two days at 40 C, eight for two hours at 50 C and one for six minutes at 60 C. There was no significant difference i~l the resistance to temperature between strains from carriers and patients.
A thesis submitted to the Cornmettee of Graduated School of Kyungpook 1ational University for .the degree of Doctor of Medical Science in August, 1974.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|